Utility of Hypertonic Saline in the Management of Acute Bronchiolitis in Infants: A Randomised Controlled Study
Abstract
Methods: One hundred consecutive patients attending Paediatrics Emergency at GMSH, Sector-16, Chandigarh between the age group of 2 to 12 months and admitted with clinical diagnosis of acute bronchiolitis were enrolled for the study.
Results: Baseline clinical symptoms and signs were comparable between the two groups. There was no significant difference found between 2 groups in relation to clinical signs (respiratory rate, RDAI, heart rate and SpO2) pre and post nebulisation on day 1 as well as on day 2. The change in clinical parameters pre and post nebulisation in 2 groups was comparable. The mean ± SD length of stay in hospital in hypertonic saline and normal saline group was 3.92 ± 1.72 days and 4.08 ± 1.90 days respectively. There was no significant difference noted between two groups (P = 0.67).
Conclusion: Nebulisation with hypertonic saline plus adrenaline and normal saline plus adrenaline are equally effective in the treatment of acute bronchiolitis in infants. Nebulisation with hypertonic saline is a safe option of treatment in acute bronchiolitis in children.
doi: http://dx.doi.org/10.4021/ijcp96w