Hemolysis in Neonates Born to Mothers With History of SARS-CoV-2 Infection During Pregnancy: A Case Series

Abstract

Hemolytic anemia has been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adult and pediatric patients. Here we report a case series of preterm newborns with hemolytic anemia whose mothers had a history of SARS-CoV-2 infection. In two of the cases maternal infection occurred early in pregnancy and the newborns had a reactive SARS-CoV-2 antibody test. Hemolysis and coagulopathy improved with the use of washed blood products and prothrombin complex concentrate. Our cases highlight the need for increased awareness of a possible association between hemolysis and exposure to SARS-CoV-2 infection during intrauterine life.

Int J Clin Pediatr. 2022;11(1):27-32
doi: https://doi.org/10.14740/ijcp479