Successfully Treating Hypercalcemia Secondary to Subcutaneous Fat Necrosis With Pamidronate: A Case Series

Ryan J. Dyess, Prasanthi Pasala Gandham, Bradly J. Thrasher


Subcutaneous fat necrosis (SCFN) is an unusual source of hypercalcemia in neonates. This condition is self-limiting; however, hypercalcemia can occur as a sequela. Severe hypercalcemia can result in increased morbidity and mortality. Several modalities of treatment for hypercalcemia subsequent to SCFN have been explored, including the use of bisphosphonates, particularly pamidronate. We briefly review SCFN, recognition of this uncommon dermatological phenomenon, as well as hypercalcemia resultant from SCFN and its current management strategy. Furthermore, we report a case series of two patients treated successfully with intravenous pamidronate in conjunction with other treatment modalities.

Int J Clin Pediatr. 2021;10(1):6-9


Subcutaneous fat necrosis; Pamidronate; Hypercalcemia; Bisphosphonates

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