An Analysis of Ultrastructure of the Hair of Children Treated With Valproic Acid

Kursat Bora Carman, Serap Sirvanci, Duygu Gursoy, Esra Carman, Coskun Yarar

Abstract


Background: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. Hair loss, color changes, thinning, and curliness have been reported in patients treated with VPA. In the present study, we aimed to analyze the ultrastructure of the hair of children treated with VPA via electron microscope.

Methods: This cross-sectional study was performed with 12 epileptic children who had been treated with VPA for at least 12 months. The hair samples of children were examined via electron microscopy.

Results: Scanning electron microscopy of hairs in patients demonstrated normal ultrastructural appearance of the hair surface and cuticular pattern.

Conclusion: The present study is retrospective. The drug-induced changes might be temporary. Therefore, prospective research projects involving larger groups might be helpful.




Int J Clin Pediatr. 2016;5(3-4):41-43
doi: https://doi.org/10.14740/ijcp257w


Keywords


Valproic acid; Hair; Analysis; Electron microscopy

Full Text: HTML PDF
　

Browse  Journals  

     

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 
 

International Journal of Clinical Pediatrics, quarterly, ISSN 1927-1255 (print), 1927-1263 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.theijcp.org   editorial contact: editor@theijcp.org    elmer.editorial2@hotmail.com
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.


Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.