International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access |
Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc |
Journal website http://www.theijcp.org |
Original Article
Volume 1, Number 1, February 2012, pages 19-24
Magnesium Sulphate Versus Sildenafil in the Treatment of Persistent Pulmonary Hypertension of the Newborn
Tables
Group S | Group M | P-value | |
---|---|---|---|
As regards clinical manifestations of PPHN, our study group presented with various degrees of respiratory distress, cyanosis, murmur and cardiomegaly diagnosed by chest X-ray and echocardiography (Table 2). | |||
Sex | |||
Male | 54 (54%) | 58 (58%) | 1 |
Female | 46 (46%) | 42 (42%) | |
Gestational age (weeks) | 37.5 ± 1.1 | 37.1 ± 1.14 | 0.6 |
Mean Age (days) | 4.2 ± 2.5 | 3.6 ± 1.3 | 0.81 |
Mode of Delivery | |||
Vaginal delivery | 29 (29%) | 31 (31%) | 1 |
Cesarean Section | 71 (71%) | 69 (69%) |
Groups | Number | Percentage | P-value | ||
---|---|---|---|---|---|
Respiratory distress | Group S | Mild | 10 | 10 | 0.150 |
Moderate | 32 | 32 | |||
Severe | 58 | 58 | |||
Group M | Mild | 12 | 30 | ||
Moderate | 29 | 0 | |||
Severe | 59 | 59 | |||
Cyanosis | Group S | 58 | 58 | 1.000 | |
Group M | 59 | 59 | |||
Murmur | Group S | 71 | 71 | 0.656 | |
Group M | 68 | 68 | |||
Cardiomegaly by chest X-ray | Group S | 59 | 59 | 0.650 | |
Group M | 63 | 63 |
Groups | Mean | Std. deviation | P. value | |
---|---|---|---|---|
EPAP before treatment (P1) mmHg | Group S | 61.5 | ± 9.8 | 0.731 |
Group M | 58.1 | ± 8.6 | ||
EPAP 48 hours after treatment (P2) mmHg | Group S | 40.4 | ± 12.2 | 0.255 |
Group M | 42.8 | ± 11.5 | ||
EPAP 5 days after treatment (P3) mmHg | Group S | 24.7 | ± 4.3 | 0.012 |
Group M | 36.2 | ± 3.6 |
Groups | Median | P. value | ||
---|---|---|---|---|
Time interval to normalization of SaO2 (days) | Group S | 2.2 | 0.02 | |
Group M | 3.5 | |||
Mean | SD | |||
Time interval to normalization of ABG (days) | Group S | 2.45 | ± 0.8 | 0.02 |
Group M | 3.70 | ± 1.2 | ||
Duration of ventilation (days) | Group S | 4.8 | ± 2.15 | 0.03 |
Group M | 6.6 | ± 2.45 |