International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access
Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc
Journal website http://www.theijcp.org

Original Article

Volume 1, Number 1, February 2012, pages 19-24


Magnesium Sulphate Versus Sildenafil in the Treatment of Persistent Pulmonary Hypertension of the Newborn

Tables

Table 1. Clinical Characteristics of Both Groups
 
Group SGroup MP-value
As regards clinical manifestations of PPHN, our study group presented with various degrees of respiratory distress, cyanosis, murmur and cardiomegaly diagnosed by chest X-ray and echocardiography (Table 2).
Sex
  Male54 (54%)58 (58%)1
  Female46 (46%)42 (42%)
Gestational age (weeks)37.5 ± 1.137.1 ± 1.140.6
Mean Age (days)4.2 ± 2.53.6 ± 1.30.81
Mode of Delivery
  Vaginal delivery29 (29%)31 (31%)1
  Cesarean Section71 (71%)69 (69%)

 

Table 2. Baseline Signs of PPHN Among Both Groups
 
GroupsNumberPercentageP-value
Respiratory distressGroup SMild10100.150
Moderate3232
Severe5858
Group MMild1230
Moderate290
Severe5959
CyanosisGroup S58581.000
Group M5959
MurmurGroup S71710.656
Group M6868
Cardiomegaly by chest X-rayGroup S59590.650
Group M6363

 

Table 3. Estimated Pulmonary Artery Pressure (EPAP) in our Study Groups
 
GroupsMeanStd. deviationP. value
EPAP before treatment (P1) mmHgGroup S61.5± 9.80.731
Group M58.1± 8.6
EPAP 48 hours after treatment (P2) mmHgGroup S40.4± 12.20.255
Group M42.8± 11.5
EPAP 5 days after treatment (P3) mmHgGroup S24.7± 4.30.012
Group M36.2± 3.6

 

Table 4. Duration to Improvement of SaO2 and ABG and Duration of Ventilation by Days in our Study Groups
 
GroupsMedianP. value
Time interval to normalization of SaO2 (days)Group S2.20.02
Group M3.5
MeanSD
Time interval to normalization of ABG (days)Group S2.45± 0.80.02
Group M3.70± 1.2
Duration of ventilation (days)Group S4.8± 2.150.03
Group M6.6± 2.45