| International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc |
| Journal website https://www.theijcp.org |
Case Report
Volume 10, Number 1, March 2021, pages 18-23
Accidental Methadone Poisoning in a Four-Year-Old Child Reversed With Continuous Intravenous Infusion of Naloxone
Tables
| Laboratory tests | Normal range | Results (5 h post ingestion) | Results (20 h post ingestion) |
|---|---|---|---|
| CBG: capillary blood gases; VBG: venous blood gases. | |||
| Complete blood count | |||
| White blood cell (WBC) | 6 - 15 × 109 /L | 18.4 × 109 / L | Not repeated |
| Neutrophil (Neut) | 1.5 - 8 × 109 /L | 10.49 × 109 /L | |
| Red blood cell (RBC) | 4.0 - 5.2 × 1012 /L | 4.6 × 1012 / L | |
| Hemoglobin (Hb) | 11 - 14 g/dL | 12.3 g/dL | |
| Platelet (Plt) | 180 - 400 × 109 /L | 441 × 109 / L | |
| Renal profile | |||
| Blood urea nitrogen (BUN) | 2.8 - 8.1 mmol/L | 4.2 mmol/L | Not repeated |
| Serum creatinine (SrCr) | 34 - 65 µmol/L | 39 µmol/L | |
| Sodium (Na+) | 136 -145 mmol/L | 140 mmol/L | |
| Potassium (K+) | 3.4 - 4.5 mmol/L | 3.8 mmol/L | |
| Liver profile | |||
| Albumin (Alb) | 35 - 50 g/L | 42 g/L | Not repeated |
| Alanine transaminases (ALT) | 10 - 40 U/L | 16 U/L | |
| Alkaline phosphatase (ALP) | < 350 U/L | 198 U/L | |
| Capillary/venous blood gas | CBG | VBG | |
| pH | 7.32 - 7.43 | 7.252 | 7.27 |
| pCO2 | 41 - 50 mm Hg | 31.9 mm Hg | 51.2 mm Hg |
| pO2 | 25 - 40 mm Hg | 49.9 mm Hg | 63.6 mm Hg |
| cHCO3- | 23 - 27 mmol/L | 14.8 mmol/L | 21.1 mmol/L |
| Base excess (BE) | -4 to +2 | -12.2 mmol/L | -3 mmol/L |
| Vital signs and clinical parameters | Before naloxone | After naloxone |
|---|---|---|
| RA: room air. | ||
| General condition | Sleepy, drowsy, needed pain stimuli to wake child | Awake, less drowsy |
| Glasgow coma scale (GCS) | GCS not done (child sleeping) | GCS full |
| Bilateral pupils | 2 mm/2 mm (equal and reactive) | 3 mm/3 mm (equal and reactive) |
| Oxygen saturation (SPO2) | 100% under RA | 100% under RA |
| Breathing pattern | Regular breathing | Regular breathing |
| Behavior | Behavioral changes (restless, crying) | Back to normal self |
| Central nervous system | Tone normal, power 5/5 | Tone normal, power 5/5 |