Int J Clin Pediatr

International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access

Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc

Journal website http://www.theijcp.org

Original Article

Volume 1, Number 2-3, June 2012, pages 63-69

Osteoprotegerin, Insulin Like Growth Factor-1 and Bone Changes in Prepubertal Males With Type 1 Diabetes Mellitus

Figures

Figure 1.

Figure 1. Correlation between OPG and IGF-1

Figure 2.

Figure 2. correlation between HbA1c and OPG

Figure 3.

Figure 3. Correlation between HbA1c and IGF-1

Tables

**Table 1.** Clinical findings of T1DM patients and controls
	Patients (n = 35) (mean ± SD)	Controls (n = 28) (mean ± SD)	P value
P values < 0.05 are significant
Age (years)	11.20 ± 2.10	10.90 ± 2.30	NS
Diabetes duration (years)	5.7 ± 2.4	-	-
Height (cm)	137.21 ± 5.40	135.10 ± 5.21	NS
Weight (Kg)	32.90 ± 1.81	29.83 ± 1.73	NS
BMI	17.40 ± 0.92	16.30 ± 0.83	NS
Bone age (years)	12.50 ± 1.20	11.10 ± 0.80	NS

**Table 2.** Laboratory findings of T1DM patients and controls
	Patients (n = 35) (mean ± SD)	Controls (n = 28) (mean ± SD)	p value
P values < 0.05 are significant
Serum intact PTH (pg/ml)	24.11 ± 7.70	26.10 ± 8.31	NS
Serum 25-OH-D (nmol/l)	36.80 ± 17.51	39.41 ± 14.12	NS
HbA1c (%)	8.12 ± 0.72	4.12 ± 1.10	P < 0.0001
OPG (pg/mL)	72.40 ± 13.81	38.90 ± 12.80	P < 0.0001
IGF-1(mg/mL)	198 ± 76	248 ± 51	P < 0.001
Z- score BUA	- 0.43 ± 0.73	0.19 ± 0.64	P < 0.0001