An Analysis of Ultrastructure of the Hair of Children Treated With Valproic Acid

Kursat Bora Carman, Serap Sirvanci, Duygu Gursoy, Esra Carman, Coskun Yarar


Background: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. Hair loss, color changes, thinning, and curliness have been reported in patients treated with VPA. In the present study, we aimed to analyze the ultrastructure of the hair of children treated with VPA via electron microscope.

Methods: This cross-sectional study was performed with 12 epileptic children who had been treated with VPA for at least 12 months. The hair samples of children were examined via electron microscopy.

Results: Scanning electron microscopy of hairs in patients demonstrated normal ultrastructural appearance of the hair surface and cuticular pattern.

Conclusion: The present study is retrospective. The drug-induced changes might be temporary. Therefore, prospective research projects involving larger groups might be helpful.

Int J Clin Pediatr. 2016;5(3-4):41-43



Valproic acid; Hair; Analysis; Electron microscopy

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